Trophectoderm Lineage Determination in Cattle
نویسندگان
چکیده
منابع مشابه
A Computational Model for Understanding Stem Cell, Trophectoderm and Endoderm Lineage Determination
BACKGROUND Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. In particular, an excess of Cdx2 over ...
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Controversy exists as to whether individual blastomeres from two-cell-stage mouse embryos have identical developmental properties and fate. We show that the transcription factor Cdx2 is expressed in the nuclei of cells derived from the late-dividing but not the first-dividing blastomere of two-cell embryos and, by lineage tracing and RNA interference knock-down experiments, that this lagging ce...
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BACKGROUND DNA methylation is reprogrammed during early embryogenesis by active and passive mechanisms in advance of the first differentiation event producing the embryonic and extraembryonic lineage cells which contribute to the future embryo proper and to the placenta respectively. Embryonic lineage cells re-acquire a highly methylated genome dependent on the DNA methyltransferases (DNMTs) Dn...
متن کاملCDX2 in the formation of the trophectoderm lineage in primate embryos.
The first lineage decision during mammalian development is the establishment of the trophectoderm (TE) and the inner cell mass (ICM). The caudal-type homeodomain protein Cdx2 is implicated in the formation and maintenance of the TE in the mouse. However, the role of CDX2 during early embryonic development in primates is unknown. Here, we demonstrated that CDX2 mRNA levels were detectable in rhe...
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"How do cells differentiate into one type or another? is one of the most fundamental questions in cell biology and is also pertinent to the problem of cell transformation, which may often involve progenitor cells [1] and derangement of developmental processes. Commitment of haemopoietic progenitor cells to differentiation along at least five distinct pathways during haemopoiesis continues throu...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2011
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2011.01.003